Pathogenicity and transmission of a swine influenza A(H6N6) virus
Identifieur interne : 000285 ( Main/Exploration ); précédent : 000284; suivant : 000286Pathogenicity and transmission of a swine influenza A(H6N6) virus
Auteurs : Hailiang Sun [États-Unis] ; Bryan S. Kaplan [États-Unis] ; Minhui Guan [États-Unis] ; Guihong Zhang [République populaire de Chine] ; Jianqiang Ye [États-Unis] ; Li-Ping Long [États-Unis] ; Sherry Blackmon [États-Unis] ; Chun-Kai Yang [États-Unis] ; Meng-Jung Chiang [États-Unis] ; Hang Xie [États-Unis] ; Nan Zhao [États-Unis] ; Jim Cooley [États-Unis] ; David F. Smith [États-Unis] ; Ming Liao [République populaire de Chine] ; Carol Cardona [États-Unis] ; Lei Li [États-Unis] ; George Peng Wang [États-Unis] ; Richard Webby [États-Unis] ; Xiu-Feng Wan [États-Unis]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2017.
Abstract
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.
Url:
DOI: 10.1038/emi.2017.3
PubMed: 28400591
PubMed Central: 5457681
Affiliations:
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Kaplan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Infectious Diseases, St Jude Children's Research Hospital</institution>, Memphis, TN 38105,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guan, Minhui" sort="Guan, Minhui" uniqKey="Guan M" first="Minhui" last="Guan">Minhui Guan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Guihong" sort="Zhang, Guihong" uniqKey="Zhang G" first="Guihong" last="Zhang">Guihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>College of Veterinary Medicine, South China Agricultural University</institution>, Guangzhou 510462, Guangdong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Jianqiang" sort="Ye, Jianqiang" uniqKey="Ye J" first="Jianqiang" last="Ye">Jianqiang Ye</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Long, Li Ping" sort="Long, Li Ping" uniqKey="Long L" first="Li-Ping" last="Long">Li-Ping Long</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blackmon, Sherry" sort="Blackmon, Sherry" uniqKey="Blackmon S" first="Sherry" last="Blackmon">Sherry Blackmon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Chun Kai" sort="Yang, Chun Kai" uniqKey="Yang C" first="Chun-Kai" last="Yang">Chun-Kai Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chiang, Meng Jung" sort="Chiang, Meng Jung" uniqKey="Chiang M" first="Meng-Jung" last="Chiang">Meng-Jung Chiang</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration</institution>, Silver Spring, MD 20993,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Hang" sort="Xie, Hang" uniqKey="Xie H" first="Hang" last="Xie">Hang Xie</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration</institution>, Silver Spring, MD 20993,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooley, Jim" sort="Cooley, Jim" uniqKey="Cooley J" first="Jim" last="Cooley">Jim Cooley</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Population Medicine and Pathobiology, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, David F" sort="Smith, David F" uniqKey="Smith D" first="David F" last="Smith">David F. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Biochemistry, Glycomics Center, School of Medicine, Emory University</institution>, Atlanta 30322, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liao, Ming" sort="Liao, Ming" uniqKey="Liao M" first="Ming" last="Liao">Ming Liao</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>College of Veterinary Medicine, South China Agricultural University</institution>, Guangzhou 510462, Guangdong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardona, Carol" sort="Cardona, Carol" uniqKey="Cardona C" first="Carol" last="Cardona">Carol Cardona</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>College of Veterinary Medicine, University of Minnesota</institution>, St Paul, MN 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Lei" sort="Li, Lei" uniqKey="Li L" first="Lei" last="Li">Lei Li</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Chemistry, Georgia State University</institution>, Atlanta, GA 30302,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, George Peng" sort="Wang, George Peng" uniqKey="Wang G" first="George Peng" last="Wang">George Peng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Chemistry, Georgia State University</institution>, Atlanta, GA 30302,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Infectious Diseases, St Jude Children's Research Hospital</institution>, Memphis, TN 38105,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>, Mississippi State, MS 39759,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sun, Hailiang" sort="Sun, Hailiang" uniqKey="Sun H" first="Hailiang" last="Sun">Hailiang Sun</name></noRegion><name sortKey="Blackmon, Sherry" sort="Blackmon, Sherry" uniqKey="Blackmon S" first="Sherry" last="Blackmon">Sherry Blackmon</name><name sortKey="Cardona, Carol" sort="Cardona, Carol" uniqKey="Cardona C" first="Carol" last="Cardona">Carol Cardona</name><name sortKey="Chiang, Meng Jung" sort="Chiang, Meng Jung" uniqKey="Chiang M" first="Meng-Jung" last="Chiang">Meng-Jung Chiang</name><name sortKey="Cooley, Jim" sort="Cooley, Jim" uniqKey="Cooley J" first="Jim" last="Cooley">Jim Cooley</name><name sortKey="Guan, Minhui" sort="Guan, Minhui" uniqKey="Guan M" first="Minhui" last="Guan">Minhui Guan</name><name sortKey="Kaplan, Bryan S" sort="Kaplan, Bryan S" uniqKey="Kaplan B" first="Bryan S" last="Kaplan">Bryan S. Kaplan</name><name sortKey="Li, Lei" sort="Li, Lei" uniqKey="Li L" first="Lei" last="Li">Lei Li</name><name sortKey="Long, Li Ping" sort="Long, Li Ping" uniqKey="Long L" first="Li-Ping" last="Long">Li-Ping Long</name><name sortKey="Smith, David F" sort="Smith, David F" uniqKey="Smith D" first="David F" last="Smith">David F. Smith</name><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name><name sortKey="Wang, George Peng" sort="Wang, George Peng" uniqKey="Wang G" first="George Peng" last="Wang">George Peng Wang</name><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name><name sortKey="Xie, Hang" sort="Xie, Hang" uniqKey="Xie H" first="Hang" last="Xie">Hang Xie</name><name sortKey="Yang, Chun Kai" sort="Yang, Chun Kai" uniqKey="Yang C" first="Chun-Kai" last="Yang">Chun-Kai Yang</name><name sortKey="Ye, Jianqiang" sort="Ye, Jianqiang" uniqKey="Ye J" first="Jianqiang" last="Ye">Jianqiang Ye</name><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Guihong" sort="Zhang, Guihong" uniqKey="Zhang G" first="Guihong" last="Zhang">Guihong Zhang</name></noRegion><name sortKey="Liao, Ming" sort="Liao, Ming" uniqKey="Liao M" first="Ming" last="Liao">Ming Liao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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